Iron Metabolism: From Molecular Mechanisms to Clinical Consequences (3rd Edition)

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Robert Crichton, "Iron Metabolism: From Molecular Mechanisms to Clinical Consequences (3rd Edition)"
2009 | ISBN: 0470010282 | 482 pages | PDF | 13 MB

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development.

Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include:
- Solution chemistry of iron in biological media
- The importance of iron for biological systems
- Microbial iron transport and metabolism
- Iron uptake by plants and fungi
- Cellular iron uptake and export in mammals
- Intracellular iron storage and biomineralization
- Intracellular iron metabolism and cellular iron homeostasis
- Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance
- Pathophysiology of iron deficiency and iron overload in man
- Iron and oxidative stress
- Brain iron homeostasis and its perturbation in various neurodegenerative diseases
- Interactions between iron and other metals

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